VarLensGenetic Variant Analysis

Secure analysis of genetic variants on the desktop or self-hosted — built for research collaborators

Variant Analysis

Browse, sort, and search variants with a powerful data table supporting custom columns, per-column text filters, and full-text search

Filtering & Search

Filter by consequence, gnomAD allele frequency, CADD score, ClinVar significance, gene symbol, and more

ACMG Classification

Classify variants using the ACMG/AMP evidence framework with Bayesian point-based scoring

Cohort Analysis

Aggregate variants across cases for carrier frequency analysis and gene burden testing

Private & Secure

Run fully offline on the desktop with all data on your machine, or self-host the web app on your own infrastructure. No third-party cloud, no tracking. SQLite or PostgreSQL, with optional encryption