VarLensOffline Genetic Variant Analysis

A desktop application for secure, offline analysis of genetic variants — built for research collaborators

Variant Analysis

Browse, sort, and search variants with a powerful data table supporting custom columns, per-column text filters, and full-text search

Filter by consequence, gnomAD allele frequency, CADD score, ClinVar significance, gene symbol, and more

Classify variants using the ACMG/AMP evidence framework with Bayesian point-based scoring

Aggregate variants across cases for carrier frequency analysis and gene burden testing

All data stays on your machine. No cloud uploads, no accounts, no tracking. SQLite database with optional encryption